Research needs

▪️ There is a need to conduct randomized controlled trials (RCTs) to determine the safety of using intrathecal fluorescein in localizing skull base defect.  

▪️  There is a need to conduct RCTs to compare between grafts and vascularized flaps in repair of skull base defects.

▪️ There is a need to conduct RCTs to detect the safety and efficacy of repair of frontal sinus leaks using the endoscopic technique.

▪️ More studies are needed to determine the ideal duration of conservative Nonsurgical management options in traumatic and iatrogenic CSF leaks.

▪️  More studies are needed to evaluate the effect and optimal duration of medical management of idiopathic increase intracranial tension