Edwardsiellosis is an acute to chronic infection that greatly increases mortality, reduces fish marketability, and decreases total productivity with increase of production costs. It is reported that the ranges for mortality and morbidity are 5% to 30% and 5% to 70%, respectively. The disease is characterized by signs of septicemia including redness of the mouth and vent, exophthalmia, abdominal distension, necrotic abscesses in the muscle of putrid odor and grayish white nodules in internal organs. As well as it has been associated with intestinal and extraintestinal infection in humans. Many types of vaccine have been developed for disease prevention such as FKC, LPS, and ECP. In addition, oxytetracycline, florfenicol, and sulphadimethoxine-ormetoprim are the common antibiotics approved by FDA for treatment of Edwardsiellosis