1- The clinical presentation can range from mild diarrhea without systemic disease to profuse, acute diarrhea associated with rapid dehydration, severe disturbance of acid-base and electrolyte balance, and death, sometimes in as few as 12 hours.

2- Dry mouth and cold skin and extremities

3- Enophthalmos (retraction of the eyeball)

4- Diarrhea can be fatal to neonatal calves due to dehydration and acidosis that may result in anorexia and ataxia

5- Weight Loss: Rapid loss of body condition due to dehydration and poor nutrient absorption.

6- Depression and Lethargy: Reduced activity and reluctance to nurse or feed.

7- Fever: Common in bacterial infections, not always present in viral or parasitic cases.

8- Abdominal Pain: Indicated by calf arching its back or grinding teeth.

9- The progression of diarrhea can be rapid required critical interference and quick diagnosis.