Aeromoniasis was the most prevalent bacterial diseases affecting freshwater and brackish fishes caused by motile aeromonads of the Aeromonas hydrophila com­plex which includes Aeromonas hydrophila, Aeromonas sobria, and Aeromnas veronii. Aeromonas hydrophila is an opportunistic bacterium that can be transmitted to stressed fish by oral and dermal routes. The bacterium restricts fish production, harms the economy, and necessitates the use of costly control methods, making it a major barrier to the growth and sustainability of the aquaculture sector. The overuse of synthetic pharmaceuticals and antibiotics results in the emergence of drug bacterial resistant strains, as well as the buildup of drug residues in fish tissues and water that may be harmful for both the environment and humans. Moreover, there was no commercial vaccine against MAS. Therefore, to date control of MAS has been a challenging issue.