Artificial Oocyte Activation (AOA) Following Intracytoplasmic Sperm Injection (ICSI)

- References

[1] Lu Z, Zhang X, Leung C, Esfandiari N, Casper RF, Sun Y: Robotic ICSI (intracytoplasmic sperm injection). IEEE transactions on bio-medical engineering 2011;58(7): 2102-2108.

[2] Kashir J, Heindryckx B, Jones C, De Sutter P, Parrington J, Coward K: Oocyte activation, phospholipase C zeta and human infertility. Human reproduction update 2010;16(6): 690-703.

[3] Vanden Meerschaut F, Nikiforaki D, Heindryckx B, De Sutter P: Assisted oocyte activation following ICSI fertilization failure. Reprod Biomed Online 2014;28(5): 560-571.

[4] Tesarik J, Sousa M, Testart J: Human oocyte activation after intracytoplasmic sperm injection. Hum Reprod 1994;9(3): 511-518.

[5] Swain JE, Pool TB: ART failure: oocyte contributions to unsuccessful fertilization. Human reproduction update 2008;14(5): 431-446.

[6] Sfontouris IA, Nastri CO, Lima ML, Tahmasbpourmarzouni E, Raine-Fenning N, Martins WP: Artificial oocyte activation to improve reproductive outcomes in women with previous fertilization failure: a systematic review and meta-analysis of RCTs. Hum Reprod 2015;30(8): 1831-1841.

[7] Alberio R, Zakhartchenko V, Motlik J, Wolf E: Mammalian oocyte activation: lessons from the sperm and implications for nuclear transfer. The International journal of developmental biology 2001;45(7): 797-809.

[8] Nasr-Esfahani MH, Deemeh MR, Tavalaee M: Artificial oocyte activation and intracytoplasmic sperm injection. Fertil Steril 2010;94(2): 520-526.

[9] Mansour R, Fahmy I, Tawab NA, Kamal A, El-Demery Y, Aboulghar M, et al.: Electrical activation of oocytes after intracytoplasmic sperm injection: a controlled randomized study. Fertil Steril 2009;91(1): 133-139.

[10] Fawzy M, Emad M, Mahran A, Sabry M, Fetih AN, Abdelghafar H, et al.: Artificial oocyte activation with SrCl2 or calcimycin after ICSI improves clinical and embryological outcomes compared with ICSI alone: results of a randomized clinical trial. Hum Reprod 2018;33(9): 1636-1644.

[11] Ruan JL, Liang SS, Pan JP, Chen ZQ, Teng XM: Artificial oocyte activation with Ca(2+) ionophore improves reproductive outcomes in patients with fertilization failure and poor embryo development in previous ICSI cycles. Front Endocrinol (Lausanne) 2023;14: 1244507.

[12] Zhang X, Li L, Zhang W, Luo Y, Mao Y, Du H, et al.: Embryo development and live birth resulted from artificial oocyte activation after microdissection testicular sperm extraction with ICSI in patients with non-obstructive azoospermia. Front Endocrinol (Lausanne) 2023;14: 1123541.

[13] Ebner T, Oppelt P, Wöber M, Staples P, Mayer RB, Sonnleitner U, et al.: Treatment with Ca2+ ionophore improves embryo development and outcome in cases with previous developmental problems: a prospective multicenter study. Hum Reprod 2015;30(1): 97-102.

[14] Yin M, Li M, Li W, Wu L, Yan Z, Zhao J, et al.: Efficacy of artificial oocyte activation in patients with embryo developmental problems: a sibling oocyte control study. Arch Gynecol Obstet 2022;305(5): 1225-1231.

[15] Shi X, Zhuo H, Du Y, Nyhan K, Ioannidis J, Wallach JD: Environmental risk factors for non-Hodgkin's lymphoma: umbrella review and comparison of meta-analyses of summary and individual participant data. BMJ medicine 2022;1(1): e000184.

[16] Fusar-Poli P, Radua J: Ten simple rules for conducting umbrella reviews. Evid Based Ment Health 2018;21(3): 95-100.

[17] World Health O. WHO handbook for guideline development. Geneva: World Health Organization. 2011.

[18] Akashi K, Yamada M, Jwa SC, Utsuno H, Kamijo S, Hirota Y, et al.: Artificial oocyte activation using Ca(2+) ionophores following intracytoplasmic sperm injection for low fertilization rate. Front Endocrinol (Lausanne) 2023;14: 1131808.

[19] Aydinuraz B, Dirican EK, Olgan S, Aksunger O, Erturk OK: Artificial oocyte activation after intracytoplasmic morphologically selected sperm injection: A prospective randomized sibling oocyte study. Hum Fertil (Camb) 2016;19(4): 282-288.

[20] Baltaci V, Ayvaz OU, Unsal E, Aktaş Y, Baltaci A, Turhan F, et al.: The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure. Fertil Steril 2010;94(3): 900-904.

[21] Bonte D, Ferrer-Buitrago M, Dhaenens L, Popovic M, Thys V, De Croo I, et al.: Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection: a 17-year retrospective study. Fertil Steril 2019;112(2): 266-274.

[22] Cheung S, Xie P, Parrella A, Keating D, Rosenwaks Z, Palermo GD: Identification and treatment of men with phospholipase Czeta-defective spermatozoa. Fertil Steril 2020;114(3): 535-544.

[23] Lam KKW, Wong JYY, Cheung TM, Li RHW, Ng EHY, Yeung WSB: A retrospective analysis of artificial oocyte activation in patients with low or no fertilisation in intracytoplasmic sperm injection cycles. J Obstet Gynaecol 2022;42(4): 648-653.

[24] Li J, Zheng X, Lian Y, Li M, Lin S, Zhuang X, et al.: Artificial oocyte activation improves cycles with prospects of ICSI fertilization failure: a sibling oocyte control study. Reprod Biomed Online 2019;39(2): 199-204.

[25] Montag M, Köster M, van der Ven K, Bohlen U, van der Ven H: The benefit of artificial oocyte activation is dependent on the fertilization rate in a previous treatment cycle. Reprod Biomed Online 2012;24(5): 521-526.

[26] Shebl O, Reiter E, Enengl S, Allerstorfer C, Schappacher-Tilp G, Trautner PS, et al.: Double ionophore application in cases with previous failed/low fertilization or poor embryo development. Reprod Biomed Online 2022;44(5): 829-837.

[27] Shebl O, Trautner PS, Enengl S, Reiter E, Allerstorfer C, Rechberger T, et al.: Ionophore application for artificial oocyte activation and its potential effect on morphokinetics: a sibling oocyte study. J Assist Reprod Genet 2021;38(12): 3125-3133.

[28] Tejera A, Alegre Ferri L, Gamiz Izquierdo P, Beltrán Torregrosa D, Alejandro Remohí J, Meseguer Escrivá M: Treatment with calcium ionophore improves the results in patients with previous unsuccessful attempts at the fertilization: A cohort study. Int J Fertil Steril 2021;15(4): 286-293.

[29] Yoon HJ, Bae IH, Kim HJ, Jang JM, Hur YS, Kim HK, et al.: Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore. J Assist Reprod Genet 2013;30(12): 1569-1575.

[30] Cheung S, Parrella A, Tavares D, Keating D, Xie P, Rosenwaks Z, et al.: Single-center thorough evaluation and targeted treatment of globozoospermic men. J Assist Reprod Genet 2021;38(8): 2073-2086.

[31] Tavalaee M, Nomikos M, Lai FA, Nasr-Esfahani MH: Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion. Reprod Biomed Online 2018;36(3): 348-355.

[32] Moreno RD: Human globozoospermia-related genes and their role in acrosome biogenesis. WIREs Mech Dis 2023;15(2): e1589.

[33] Borges E, Jr., de Almeida Ferreira Braga DP, de Sousa Bonetti TC, Iaconelli A, Jr., Franco JG, Jr.: Artificial oocyte activation using calcium ionophore in ICSI cycles with spermatozoa from different sources. Reprod Biomed Online 2009;18(1): 45-52.

[34] Deemeh MR, Tavalaee M, Nasr-Esfahani MH: Health of children born through artificial oocyte activation: a pilot study. Reprod Sci 2015;22(3): 322-328.

[35] Li B, Zhou Y, Yan Z, Li M, Xue S, Cai R, et al.: Pregnancy and neonatal outcomes of artificial oocyte activation in patients undergoing frozen-thawed embryo transfer: a 6-year population-based retrospective study. Arch Gynecol Obstet 2019;300(4): 1083-1092.

[36] Lv M, Zhang D, He X, Chen B, Li Q, Ding D, et al.: Artificial oocyte activation to improve reproductive outcomes in couples with various causes of infertility: a retrospective cohort study. Reprod Biomed Online 2020;40(4): 501-509.

[37] Vanden Meerschaut F, Nikiforaki D, De Gheselle S, Dullaerts V, Van den Abbeel E, Gerris J, et al.: Assisted oocyte activation is not beneficial for all patients with a suspected oocyte-related activation deficiency. Hum Reprod 2012;27(7): 1977-1984.

[38] Ebner T, Montag M: Artificial oocyte activation: evidence for clinical readiness. Reproductive BioMedicine Online 2016;32(3): 271-273.

[39] Cardona Barberan A, Bonte D, Boel A, Thys V, Paredis R, Machtelinckx F, et al.: Assisted oocyte activation does not overcome recurrent embryo developmental problems. Hum Reprod 2023;38(5): 872-885.

[40] Chen X, Zhao H, Lv J, Dong Y, Zhao M, Sui X, et al.: Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles. BMC Pregnancy Childbirth 2022;22(1): 894.

[41] Mateizel I, Santos-Ribeiro S, Segers I, Wouters K, Mackens S, Verheyen G: Effect of A23187 ionophore treatment on human blastocyst development-a sibling oocyte study. J Assist Reprod Genet 2022;39(6): 1225-1232.

[42] Anagnostopoulou C, Maldonado Rosas I, Singh N, Gugnani N, Chockalingham A, Singh K, et al.: Oocyte quality and embryo selection strategies: a review for the embryologists, by the embryologists. Panminerva Med 2022;64(2): 171-184.

[43] Economou KA, Christopikou D, Tsorva E, Davies S, Mastrominas M, Cazlaris H, et al.: The combination of calcium ionophore A23187 and GM-CSF can safely salvage aged human unfertilized oocytes after ICSI. J Assist Reprod Genet 2017;34(1): 33-41.

[44] Esbert M, Carmody A, Ballesteros A, Seli E, Scott RT: Calcium Ionophore A23187 treatment to rescue unfertilized oocytes: a prospective randomized analysis of sibling oocytes. Reprod Biomed Online 2022;45(5): 878-883.

[45] Shibahara T, Fukasaku Y, Hayashi N, Miyazaki N, Kawato H, Minoura H: Early rescue oocyte activation for activation-impaired oocytes with no second polar body extrusion after intracytoplasmic sperm injection. J Assist Reprod Genet 2021;38(5): 1061-1068.

[46] Xue L, Wang S, Wei P, Liu H, Mao X, Qin J, et al.: Early rescue oocyte activation at 5 h post-ICSI is a useful strategy for avoiding unexpected fertilization failure and low fertilization in ICSI cycles. Front Endocrinol (Lausanne) 2023;14: 1301505.

[47] Swann K: The role of Ca(2+) in oocyte activation during In Vitro fertilization: Insights into potential therapies for rescuing failed fertilization. Biochim Biophys Acta Mol Cell Res 2018;1865(11 Pt B): 1830-1837.

[48] Long R, Wang M, Yang QY, Hu SQ, Zhu LX, Jin L: Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis. Reprod Biol Endocrinol 2020;18(1): 123.

[49] Asa E, Janatifar R, Saeideh Sahraei S, Verdi A, Kalhor N: The effect of cult-active medium on pregnancy outcomes after intracytoplasmic sperm injection in azoospermic men: A case-control study. Int J Reprod Biomed (Yazd) 2021;19(12): 1059-1066.

[50] Borges E, Jr., de Almeida Ferreira Braga DP, de Sousa Bonetti TC, Iaconelli A, Jr., Franco JG, Jr.: Artificial oocyte activation with calcium ionophore A23187 in intracytoplasmic sperm injection cycles using surgically retrieved spermatozoa. Fertil Steril 2009;92(1): 131-136.

[51] Ebner T, Köster M, Shebl O, Moser M, Van der Ven H, Tews G, et al.: Application of a ready-to-use calcium ionophore increases rates of fertilization and pregnancy in severe male factor infertility. Fertil Steril 2012;98(6): 1432-1437.

[52] Elmahdy M, Oreif Y, Musleh S, Khalifa E: Is there any role for calcium ionophore in ICSI cycles for cases of non obstructive azoospermia? Open J Obstet Gynecol 2021;11(08): 1037-1049.

[53] Kang HJ, Lee S-H, Park Y-S, Lim CK, Ko DS, Yang KM, et al.: Artificial oocyte activation in intracytoplasmic sperm injection cycles using testicular sperm in human in vitro fertilization. Clin Exp Reprod Med 2015;42(2): 45-50.

[54] Eftekhar M, Janati S, Rahsepar M, Aflatoonian A: Effect of oocyte activation with calcium ionophore on ICSI outcomes in teratospermia: A randomized clinical trial. Iran J Reprod Med 2013;11(11): 875-882.

[55] Heindryckx B, De Gheselle S, Gerris J, Dhont M, De Sutter P: Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection. Reprod Biomed Online 2008;17(5): 662-668.

[56] Karabulut S, Aksünger Ö, Ata C, Sağıroglu Y, Keskin İ: Artificial oocyte activation with calcium ionophore for frozen sperm cycles. Syst Biol Reprod Med 2018;64(5): 381-388.

[57] Moaz MN, Khattab S, Foutouh IA, Mohsen EA: Chemical activation of oocytes in different types of sperm abnormalities in cases of low or failed fertilization after ICSI: a prospective pilot study. Reprod Biomed Online 2006;13(6): 791-794.

[58] Nasr-Esfahani MH, Razavi S, Javdan Z, Tavalaee M: Artificial oocyte activation in severe teratozoospermia undergoing intracytoplasmic sperm injection. Fertil Steril 2008;90(6): 2231-2237.

[59] Nasr-Esfahani MH, Tavalaee M, Deemeh M, Arbabian M, Parrington J: Can Assessment of Total Acrosin Activity Help Predict Failed or Low Fertilization Rate ICSI for Implementation of Artificial Oocyte Activation? Open Andrology Journal 2010;2.

[60] Nazarian H, Azad N, Nazari L, Piryaei A, Heidari MH, Masteri-Farahani R, et al.: Effect of Artificial Oocyte Activation on Intra-Cytoplasmic Sperm Injection Outcomes in Patients with Lower Percentage of Sperm Containing Phospholipase Cζ: A Randomized Clinical Trial. J Reprod Infertil 2019;20(1): 3-9.