Critical Limb Threatening Ischemia

- Glossary

Critical limb-threatening ischemia (CLTI) is a clinical syndrome defined by the presence of peripheral artery disease (PAD) in combination with rest pain, gangrene, or a lower limb ulceration >2 weeks duration. CLTI is associated with amputation, increased mortality, and impaired quality of life. All patients with suspected CLTI should be referred urgently to a vascular specialist.